INSPIRE-study - International Neonatal tranSfusion PoInt pREvalence
Most preterm babies admitted to a Neonatal Intensive Care Unit (NICU) receive blood transfusions. Some neonates, however, receive blood transfusions even though these transfusions may not be necessary, cause side effects or even harm. There are no international guidelines that have been incorporated into clinical practice by Europe as a whole, and there is significant variation in transfusion practice within Europe. Additionally, high quality data on neonatal transfusion practice in Europe is lacking.
Therefore, the International Neonatal tranSfusion PoInt pREvalence study (INSPIRE) aims to describe the current state and indications for blood transfusions among preterm babies in Europe. Another goal of the study is to describe the use of guidelines and variation between different countries.
Description and impact of the INSPIRE-study
Preterm babies with a gestational age of less than 32 weeks at birth who are admitted to a tertiary level NICU are included in the study. Over 60 NICUs from 19 European countries will participate in the study. Study data will be collected over a one-year period, in which each participating NICU will collect data during six weeks.
The study will describe current neonatal transfusion practices within Europe. These results will help to improve practice, develop future clinical studies, and inform guideline writing. Additionally, the results may help to reduce unnecessary transfusions through increased awareness for the proper use of transfusions in this vulnerable patient group.
The Neonatal Transfusion Network (NTN)
The INSPIRE-study is performed by the Neonatal Transfusion Network (NTN), an international, interdisciplinary neonatal transfusion research network. NTN aims to improve current transfusion practices and generate more evidence for neonatal transfusion medicine.
The role of EFCNI
In collaboration with NTN, EFCNI coordinates an international parental advisory board (PAB). This board will provide input and feedback on project materials, such as the study protocol. The PAB is chaired by EFCNI and meets on a regular basis throughout the duration of the project. Furthermore, EFCNI gives advice and provides input on topics related to ethics and patient information throughout the project.
Note about funding
The INSPIRE-study is funded by the Sanquin Blood Supply Foundation (the Dutch Blood Bank), the European Society for Pediatric Research (ESPR) and the European Blood Alliance (EBA).